About
I am a neuroscientist with wide range of experience in leading and implementing basic and translational research projects, focused on neurodevelopmental and psychiatric disorders. I am a principal investigator at Stanley Center of Broad Institute with appointments at McGovern Institute for Brain Research at Massachusetts Institute of Technology (MIT), Massachusetts General Hospital (MGH) and Harvard Medical School. Scientific thought leader and innovator, skilled in animal model research, complex brain surgeries, brain circuit manipulation using viral vectors, neurophysiology, functional neuroimaging, cognition and behavioral approaches for preclinical testing and gene therapy. Member of institutional regulatory and policy making body for rational use of animal models. Investigator, motivator and leader in managing interdisciplinary and multi-institutional, international projects with team members from diverse backgrounds. Deeply committed to collaboratively tackling brain disorders using translational approaches. I am also an associate editor for the academic journal Frontiers in Systems Neuroscience. Co-Investigator for several federal grants with combined funding of 40+ million, and have authored over 50 peer reviewed publications in high-impact journals including Science, Nature, Nature Neuroscience, Neuron, and Cell (selected publications below).
Resume
Currently developing accurate models for basic and translational research in neuro-developmental and neuropsychiatric disorders, particularly autism and schizophrenia.
Experience
Group Leader
Stanley Center, Broad Institute of MIT and Harvard
Sept 2021 to present
Group Leader & Research Scientist
McGovern Institute for Brain Research
Jan 2018 to present
Principal Investigator
MGH/HST Martinos Center for Biomedical Imaging
Jan 2006 to Present
Research Scientist
MIT Brain and Cognitive Sciences
Jan 2006 to Jan 2018
Research Scientist
Picower Institute for Learning and Memory
Jan 1998 to Jan 2012
Postdoctoral Fellow
MIT Brain and Cognitive Sciences
Jan 1994 to Jan 1998
Education
Postdoctoral Fellowship (NIH Fogarty Fellow)
Massachusetts Institute of Technology
Jan 1994 to Jan 1998
Doctor of Philosophy, Biomedical and Medical Engineering
Indian Institute of Technology Delhi / All India Institute of Medical Sciences
1991
Selected Publications
Genetic Engineering of Nonhuman Primate Models for Studying Neurodevelopmental Disorders
Translational Research Methods in Neurodevelopmental Disorders / Sep 30, 2022
Toward next-generation primate neuroscience: A collaboration-based strategic plan for integrative neuroimaging
Neuron / Jan 5, 2022
Hemodynamic molecular imaging of tumor-associated enzyme activity in the living brain
eLife / Dec 21, 2021
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset
Nature Neuroscience / Dec 9, 2021
Allometric rules for mammalian cortical layer 5 neuron biophysics
Nature / Nov 10, 2021
Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans
Nature Neuroscience / Aug 17, 2020
Atypical behaviour and connectivity in SHANK3-mutant macaques
Nature / Jun 12, 2019
Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits
Cell Reports / Apr 11, 2017
Opportunities and challenges in modeling human brain disorders in transgenic primates
Nature Neuroscience / Aug 26, 2016
β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome
PNAS / Jun 23, 2014
Skills
Biomarker Discovery
Translational Research
In Vivo Electrophysiology
Gene Therapy
Functional MRI
Scientific Project Management
Biomedical Imaging
Clinical Engineering
Viral Vectors
Cognitive Neuroscience
Contact me at jeetu@mit.edu
